特定非営利活動法人医用ミニブタ研究所

概　　要
事業内容
クラウン系ミニブタ
を用いた主な論文報告
(2010年以降)

クラウン系ミニブタを用いた主な論文報告(2010年以降)

42	Preliminary Report of De Novo Adipogenesis Using Novel Bioabsorbable Implants and Image Evaluation Using A Porcine Model. Ogino S, Yamada A, Kambe Y, Nakano T, Lee S, Sakamoto M, Kato Y, Okumura S, Okano J, Yamauchi K, Suzuki Y, Yamaoka T, Morimoto N. J Artif Organs. 2022 Mar 2.
41	High-quality porcine islets isolated from aged miniature pigs. Shinohara K, Chujo D, Tamura-Nakano M, Kurokawa T, Matsumoto S, Shimoda M. Xenotransplantation. 2021 May;28(3):e12675.
40	Covering Post-Endoscopic Submucosal Dissection Ulcers in Miniature Swine with Hexanoyl (Hx:C6) Group-Modified Alkaline-Treated Gelatin Porous Film (HAG) Induces Proper Healing by Decreasing Inflammation and Fibrosis. Maeda H, Sasaki F, Morinaga Y, Kabayama M, Iwaya H, Komaki Y, Arima S, Nasu Y, Tanoue S, Hashimoto S, Kanmura S, Nishiguchi A, Taguchi T, Ido A. Digestion. 2021;102(3):415-427.
39	Enhancement of tendon-bone interface healing and graft maturation with cylindrical titanium-web (TW) in a miniature swine anterior cruciate ligament reconstruction model: histological and collagen-based analysis. Ryu K, Saito M, Kurosaka D, Kitasato S, Omori T, Hayashi H, Kayama T & Marumo K. BMC Musculoskeletal Disorders. 2020 Mar 31;21(1):198.
38	Catechin and caffeine contents in green tea at different harvest periods and their metabolism in miniature swine. Wakamatsu M, Yamanouchi H, Sahara H, Iwanaga T, Kuroda, R, Yamamoto A, Minami Y, Sekijima M, Yamada K, Kajiya K. Food Science & Nutrition. 2019 Jul 28;7(8):2769-2778.
37	Preparation of hybrid porcine thymus containing non-human primate thymic epithelial cells in miniature swine. Sekijima M, Sahara H, Shimizu A, Iwanaga T, Murokawa T, Ariyoshi Y, Pomposelli T, Khosravi Maharlooei M, Sykes M, Yamada K. Xenotransplantation. 2019 Jul 10:e12543
36	The Protective Effects of Carbon Monoxide Against Hepatic Warm Ischemia-Reperfusion Injury in MHC-Inbred Miniature Swine. Murokawa T, Sahara H, Sekijima M, Pomposelli T, Iwanaga T, Ichinari Y, Shimizu A, Yamada K. Journal of Gastrointestinal Surgery. 2020 May;24(5):974-982.
35	Application of induced pluripotent stem cells for cartilage regeneration in CLAWN miniature pig osteochondral replacement model. Uto S, Nishizawa S, Hikita A, Takato T, Hoshi K. Journal of Regenerative Therapy. 2018 Aug 24;9:58-70.
34	Pedicle screws with a thin hydroxyapatite coating for improving fixation at the bone-implant interface in the osteoporotic spine: experimental study in a porcine model. Ohe M, Moridaira H, Inami S, Takeuchi D, Nohara Y, Taneichi H. Journal of Neurosurgery. 2018 Mar 30:1-9.
33	Evaluation of the physiology of miniature pig fed Shochu distillery waste using mRNA expression profiling. Miura S, Takahashi J, Iwahashi H. Journal of Material Cycles and Waste Management. 2018 20:237-244.
32	Novel regenerative therapy combined with transphrenic peritoneoscopy-assisted omentopexy. Kainuma S, Nakajima K, Miyagawa S, Fukushima S, Saito A, Harada A, Hirota M, Miyazaki Y, Sawabata N, Watabe T, Watabe H, Toda K, Hatazawa J, Okumura M, Sawa Y. Interactive Cardiovascular and Thoracic Surgery. 2018 Jun 1;26(6):993-1001.
31	Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine. Sekijima M, Sahara H, Miki K, Villani V, Ariyoshi Y, Iwanaga T, Tomita Y, Yamada K. Journal of Surgical Research. 2017 Nov;219:165-17.
30	Histopathological background data of the systemic organs of CLAWN miniature swine with coronary artery stent implantation. Isobe A, Tasaki M, Inoue T, Terao H, Souba J, Nagano K, Hagiwara H. Journal of Toxicologic Pathology. 2017 Jan; 30(1): 25–38.
29	Effect of chymase activity on skin thickness in the Clawn miniature pig hypertrophic scarring model. Jimi S, Matsumura S. Journal of Plastic Surgery and Hand Surgery. 2017 Apr 6:1-7.
28	293 cells express both epithelial as well as mesenchymal cell adhesion molecules. Inada M, Izawa G, Kobayashi W, Ozawa M. International Journal of Molecular Medicine. 2016 Jun;37(6):1521-7.
27	Development of the intestinal transplantation model with major histocompatibility complex inbred CLAWN miniature swine. Miura K, Sahara H, Waki S, Kawai A, Sekijima M, Kobayashi T, Zhang Z, Wakai T, Shimizu A, Yamada K. Transplantation Proceedings. 2016 May;48(4):1315-9
26	Isolation and characterization of embryonic ameloblast lineage cells derived from tooth buds of fetal miniature swine. Nakahara T, Tominaga N, Toyomura J, Tachibana T, Ide Y, Ishikawa H. In Vitro Cell Dev Biol Anim. 2016 Apr;52(4):445-53.
25	Preincubation with green tea polyphenol extract is beneficial for attenuating sperm injury caused by freezing-thawing in swine. Kitaji H, Ookutsu S, Sato M, Miyoshi K. Animal Science Journal. 2015 Nov;86(11):922-8
24	Characterization of platelet aggregation responses in microminipigs: Comparison with miniature pigs and the influence of dual antiplatelet administration of aspirin plus prasugrel. Ohno K, Tomizawa A, Jakubowski JA, Mizuno M, Sugidachi A. Thrombosis Research 2015 May;135(5):933-8
23	Pilot study on interferon-γ-producing T cell subsets after the protective vaccination with radiation-attenuated cercaria of schistosoma japonicum in the miniature pig model. Abdel-Hafeez EH, Watanabe K, Kamei K, Kikuchi M, Chen H, Daniel B, Yu C, Hirayama K. Tropical Medicine and Health. 2014 Dec; 42(4): 155–162.
22	Protective effect of neutralization of the extracellular high-mobility group box 1 on renal ischemia-reperfusion injury in miniature swine. Miura K, Sahara H, Sekijima M, Kawai A, Waki S, Nishimura H, Setoyama K, Clayman ES, Shimizu A, Yamada K. Transplantation. 2014 Nov 15;98(9):937-43.
21	Novel swine model of transfusion-related acute lung injury. Okazaki H, Ishikawa O, Iijima T, Kohira T, Teranishi M, Kawasaki S, Saito A, Mikami Y, Sugiura A, Hashimoto S, Shimada E, Uchikawa M, Matsuhashi M, Tsuno NH, Tanaka M, Kiyokawa N, Fujimoto J, Nagase T, Tadokoro K, Takahashi K. Transfusion. 2014 Dec;54(12):3097-107
20	MHC-matched induced pluripotent stem cells can attenuate cellular and humoral immune responses but are still susceptible to innate immunity in pigs. Mizukami Y, Abe T, Shibata H, Makimura Y, Fujishiro SH, Yanase K, Hishikawa S, Kobayashi E, Hanazono Y. PLoS One. 2014 Jun 13;9（6）:e98319.
19	Postnatal mandibular cheek tooth development in the miniature pig based on two-dimensional and three-dimensional X-ray analyses. Ide Y, Nakahara T, Nasu M, Matsunaga S, Iwanaga T, Tominaga N, Tamaki Y. Anat Rec (Hoboken). 2013 Aug;296(8):1247-54.
18	Isolation and characterization of vascular endothelial cells derived from fetal tooth buds of miniature swine. Nasu M, Nakahara T, Tominaga N, Tamaki Y, Ide Y, Tachibana T, Ishikawa H. In Vitro Cell Dev Biol Anim. 2013 Mar;49(3):189-95.
17	Generation of naive-like porcine-induced pluripotent stem cells capable of contributing to embryonic and fetal development. Fujishiro SH, Nakano K, Mizukami Y, Azami T, Arai Y, Matsunari H, Ishino R, Nishimura T, Watanabe M, Abe T, Furukawa Y, Umeyama K, Yamanaka S, Ema M, Nagashima H, Hanazono Y. Stem Cells Dev. 2013 Feb 1;22(3):473-82.
16	Transient ligation of umbilical vessels elevates placental tissue oxygen index (TOI) values measured by near-infrared spectroscopy (NIRS) in clawn miniature pig animal model. Suzukin K, Itoh H, Muramatsu K, Yamazaki K, Nagahashi K, Furuta N, Tamura N, Uchida T, Sugihara K, Sumimoto K, Kanayama N. Clin Exp Obstet Gynecol. 2012;39(3):293-8.
15	Oligonucleotide microarray analysis of dietary-induced hyperlipidemia gene expression profiles in miniature pigs. Takahashi J, Waki S, Matsumoto R, Odake J, Miyaji T, Tottori J, Iwanaga T, Iwahashi H. PLoS One. 2012;7(5):e37581.
14	Porcine MHC classical class I genes are coordinately expressed in superantigen-activated mononuclear cells. Kametani Y, Ohshima S, Kita YF, Shimada S, Kamiguchi H, Shiina T, Inoko H, Kulski JK, Ando A. Vet Immunol Immunopathol. 2012 Aug 15;148(3-4):252-9.
13	Effect of postactivation treatment with latrunculin A on in vitro and in vivo development of cloned embryos derived from kidney fibroblasts of an aged Clawn miniature boar. Himaki T, Mizobe Y, Tsuda K, Suetomo M, Yamakuchi H, Miyoshi K, Takao S, Yoshida M. J Reprod Dev. 2012;58(4):398-403.
12	The usefulness of basic fibroblast growth factor for radiation-exposed tissue. Kinoshita N, Tsuda M, Hamuy R, Nakashima M, Nakamura-Kurashige T, Matsuu-Matsuyama M, Hirano A, Akita S. Wound Repair Regen. 2012 Jan-Feb;20(1):91-102.
11	Hepatocyte growth factor sustains T regulatory cells and prolongs the survival of kidney allografts in major histocompatibility complex-inbred CLAWN-miniature swine. Oku M, Okumi M, Shimizu A, Sahara H, Setoyama K, Nishimura H, Sada M, Scalea J, Ido A, Sachs DH, Tsubouchi H, Yamada K. Transplantation. 2012 Jan 27;93(2):148-55.
10	Application of high-resolution, massively parallel pyrosequencing for estimation of haplotypes and gene expression levels of swine leukocyte antigen (SLA) class I genes. Kita YF, Ando A, Tanaka K, Suzuki S, Ozaki Y, Uenishi H, Inoko H, Kulski JK, Shiina T. Immunogenetics. 2012 Mar;64(3):187-99.
9	Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles. Sakai K, Hashimoto Y, Baba S, Nishiura A, Matsumoto N. Dental Materials Journal. 2011; 30(6): 913–922.
8	Cultivation with untransfected fibroblasts stimulates proliferation of a single gene-modified fibroblast derived from a clawn miniature swine foetus. Sato M, Yoshida M, Miyoshi K, Ohtsuka M, Watanabe S. Reprod Domest Anim. 2011 Oct;46(5):911-6.
7	Oligonucleotide microarray analysis of age-related gene expression profiles in miniature pigs. Takahashi J, Misawa M, Iwahashi H. PLoS One. 2011;6(5):e19761.
6	Abundant expression of KCNE1 in the left ventricle of the miniature pig. Soma K, Nagaoka K, Kuwahara M, Tsubone H, Ito K. Heart Vessels. 2011 May;26(3):353-6.
5	Beneficial effects of perioperative low-dose inhaled carbon monoxide on pulmonary allograft survival in MHC-inbred CLAWN miniature swine. Sahara H, Shimizu A, Setoyama K, Oku M, Okumi M, Nishimura H, Oriyanhan W, Tasaki M, Scalea J, Wada H, Bando T, Date H, Yamada K. Transplantation. 2010 Dec 27;90(12):1336-43.
4	Effects of trichostatin A on in vitro development and transgene function in somatic cell nuclear transfer embryos derived from transgenic Clawn miniature pig cells. Himaki T, Yokomine TA, Sato M, Takao S, Miyoshi K, Yoshida M. Anim Sci J. 2010 Oct;81(5):558-63.
3	Latrunculin a dramatically improves the developmental capacity of nuclear transfer embryos derived from gene-modified clawn miniature pig cells. Himaki T, Mori H, Mizobe Y, Miyoshi K, Sato M, Takao S, Yoshida M. Cell Reprogram. 2010 Apr;12(2):127-31.
2	Carbon monoxide reduces pulmonary ischemia-reperfusion injury in miniature swine. Sahara H, Shimizu A, Setoyama K, Okumi M, Oku M, Samelson-Jones E, Yamada K. J Thorac Cardiovasc Surg. 2010 Jun;139(6):1594-601.
1	Sequence polymorphisms in porcine homologs of murine coat colour-related genes. Okumura N, Hayashi T, Uenishi H, Fukudome N, Komatsuda A, Suzuki A, Shibata M, Nii M, Yamaguchi T, Kojima-Shibata C, Hamasima N, Awata T. Anim Genet. 2010 Apr;41(2):113-21.